XIANLIANG HOU1,2,3,#, DONGE TANG1,#, FENGPING ZHENG1,#, MINGLIN OU3, YONG XU1, HUIXUAN XU1, XIAOPING HONG4, XINZHOU ZHANG1, WEIER DAI5, DONGZHOU LIU4,*, YONG DAI1,*
BIOCELL, Vol.44, No.4, pp. 559-582, 2020, DOI:10.32604/biocell.2020.011022
Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by abnormal cellular and
humoral immune responses and excessive autoantibody production. The precise pathologic mechanism of SLE remains
elusive. The advent of single-cell RNA sequencing (scRNA-seq) enables unbiased analysis of the molecular differences of
cell populations at the single-cell level. We used scRNA-seq to profile the transcriptomes of peripheral blood
mononuclear cells from an SLE patient compared with a healthy control (HC). A total of 16,021 cells were analyzed
and partitioned into 12 distinct clusters. The marker genes of each cluster and the four major immune cell types
(B cells,… More >
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