Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (1)
  • Open Access

    ARTICLE

    Expression profiling of immune cells in systemic lupus erythematosus by single-cell RNA sequencing

    XIANLIANG HOU1,2,3,#, DONGE TANG1,#, FENGPING ZHENG1,#, MINGLIN OU3, YONG XU1, HUIXUAN XU1, XIAOPING HONG4, XINZHOU ZHANG1, WEIER DAI5, DONGZHOU LIU4,*, YONG DAI1,*

    BIOCELL, Vol.44, No.4, pp. 559-582, 2020, DOI:10.32604/biocell.2020.011022 - 24 December 2020

    Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by abnormal cellular and humoral immune responses and excessive autoantibody production. The precise pathologic mechanism of SLE remains elusive. The advent of single-cell RNA sequencing (scRNA-seq) enables unbiased analysis of the molecular differences of cell populations at the single-cell level. We used scRNA-seq to profile the transcriptomes of peripheral blood mononuclear cells from an SLE patient compared with a healthy control (HC). A total of 16,021 cells were analyzed and partitioned into 12 distinct clusters. The marker genes of each cluster and the four major… More >

Displaying 1-10 on page 1 of 1. Per Page