Jiandong Guo, Huihua You, Dong Li
Oncology Research, Vol.27, No.5, pp. 601-611, 2019, DOI:10.3727/096504018X15399945637736
Abstract Baicalein, an active ingredient separated from Astragalus membranaceus, has shown its anticancer ability in
various cancers. However, its effect on nasopharyngeal carcinoma has not been explored yet. The present study
aimed to investigate the effect of baicalein on the growth, proliferation, apoptosis, and cell cycle of human
nasopharyngeal carcinoma cells, as well as transplanted nude mouse xenograft. The results showed that baicalein inhibited the growth and proliferation of CNE1 and CNE2 cells in a time- and concentration-dependent
manner. It also caused a significant increase in the number of cells in the G0/G1 phase and a decrease in the
G2/M phase,… More >
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