HAN NIU^1,#, XIN CHEN^1,#, XUEQI FU¹, JINGTIAN ZHANG¹, GUODONG LI⁴, YUXIANG WANG¹, JIAYUE SONG¹, XUETING MA¹, CHEN HU⁵, XUEMIN XU³, FUQIANG ZHANG^2,*, LINLIN ZENG^1,*

BIOCELL, Vol.45, No.4, pp. 963-970, 2021, DOI:10.32604/biocell.2021.015297

Abstract Amyotrophic lateral syndrome (ALS) is a progressive degenerative disorder characterized by motor neuron death and axon degeneration. Mitochondrial dysfunction plays a key role in the pathogenesis of ALS, the mechanism of which remains poorly understood. The B-cell lymphoma-2 (Bcl-2) family of proteins that control and mediate mitochondrial function and apoptosis, including the pro-apoptotic members Bcl2-Associated X (Bax), are involved in ALS development. The death receptor 6 (DR6) regulates motor neuron death in ALS, and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6. Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced… More >

ANNIE JOUBERT^1*, SUMARI MARAIS¹, CHRISTINE MARITZ²

BIOCELL, Vol.33, No.1, pp. 67-70, 2009, DOI:10.32604/biocell.2009.33.067

Abstract Proteins of the B-cell lymphoma 2 family are crucial for the regulation of apoptosis. B-cell lymphoma 2-associated X is a pro-apoptotic protein, while B-cell lymphoma 2 protein opposes apoptosis. The influence of 1 μM 2-methoxyestradiol was investigated on the expression levels of these two proteins in MCF-7 cells. 2-Methoxyestradiol exposure did not influence B-cell lymphoma 2 protein expression levels after 24 h of exposure. In contrast, B-cell lymphoma 2-associated X protein levels were significantly reduced. An improved differential interference contrasting technique revealed compromised cell density and the presence of a mitotic block in exposed cells. The study proposes that the… More >

Hernández LF^1,2, MV Rosetti¹

Phyton-International Journal of Experimental Botany, Vol.85, pp. 291-296, 2016, DOI:10.32604/phyton.2016.85.291

Abstract The involucral bracts (IB or phyllaries) of the sunflower (Helianthus annuus L.) capitulum constitute an example of photosynthesizing organs that contribute to the photosynthesis budget during the generation of crop yield. The anatomy of IB was analyzed in two domesticated primitive sunflower genotypes, Havasupai and Hopi, in the sunflower line HA89B, in the wild Helianthus annuus ssp. annuus, in the sunflower male-fertile line R013 and in the commercial hybrid DKOP3845. Stomata and trichomes were counted on the adaxial and abaxial epidermis. In all cases, the IB showed a one-layered adaxial and abaxial epidermis, secretory ducts and parenchymatic cells with abundant… More >

Moya ME^1,2, AA Galussi^1,2, MJ Gómez^1,2, FG Marchese^1,2

Phyton-International Journal of Experimental Botany, Vol.84, No.1, pp. 176-183, 2015, DOI:10.32604/phyton.2015.84.176

Abstract The aim of the present work was to analyze the foliar anatomy in lamina transverse section an in epidermis superficial view of Mnesithea selloana. Epidermic preparations and transections were carried out of the medium leaf part of sterile innovations that were conditioned and observed with optic microscope (OM) and scanning electron microscope (SEM).The histofoliar characteristics observed were: epidermic, intercostal, subsidiary, suberose, silicea and bulliform cells; and also guard cells, hairs, waxes, mesophylls, Kranz sheath, vascular bundles, sclerenchyma, colourless parenchyma and leaf margin. Epidermic observations showed that M. selloana presents a panicoid type epidermis presenting silicic cells as halteriforme, longer than… More >

Bryan Pfister¹, George Oyler², Michael Betenbaugh³, Gang Bao⁴

Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 233-244, 2004, DOI:10.3970/mcb.2004.001.233

Abstract The Bcl-2 family of proteins has recently been implicated as a possible player in the complex cascade of neural cell death due to traumatic brain injuries. However, it is unclear if the Bcl-2 pathways are activated in mechanically injured neurons. Here we report the effects of BclX_L and Bax over-expression on stretch-induced neural cell death using an in vitro uniaxial stretch model of traumatic axonal injury. Specifically, YFP, YFP-tagged Bax and YFP-tagged BclX_L proteins were expressed in differentiated NG108-15 cells and stretch-injury assays were carried out at different strain and strain rate combinations. As a control, insults known to act… More >

HAIFENG WANG^1,2, KAI WANG¹, JUAN GUO¹, TIEQIAO WEN²

BIOCELL, Vol.43, No.2, pp. 59-64, 2019, DOI:10.32604/biocell.2019.05731

Abstract Histone deacetylation is a key modulator involved in cell proliferation, apoptosis, and mRNA transcription. However, the effects of histone deacetylation on C17.2 neural stem cells (NSCs) remain unclear. Here, the histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) were used to determine the role of histone deacetylation on gene transcription in NSCs. The results showed that the mRNA expression of p53, Sox1, Sox2, and Bax were significantly higher in E14.5 NSCs than in C17.2 NSCs. Nestin, a marker gene of neuronal differentiation, did not differ significantly between E14.5 NSCs and C17.2 NSCs. The transcription levels of p53 and Nestin were… More >