MENGMENG LIU1,#, YUE PAN1,2,#, XUFENG TAO1, WENLI KANG1, YINGJIE LIU1, YONGJIE YANG3,4,*, GARY GUISHAN XIAO1,*
BIOCELL, Vol.46, No.10, pp. 2257-2265, 2022, DOI:10.32604/biocell.2022.020325
Abstract Pancreatic ductal adenocarcinoma (PDAC) is universally acknowledged as the cancer with the highest mortality
rate. Berberine has high medicinal value and has been used as an anti-cancer agent. Hence the purpose of this study was to
investigate the anti-cancer effect of berberine in PDAC. Berberine was shown to have a selective anti-cancer effect on
PDAC by MTT assay in vitro. Pancreatic cancer stem cells (PCSCs), regulated by epithelial–mesenchymal transition
(EMT), could promote the proliferation of PDAC cells. However, berberine suppressed the proliferation and stemness
of PCSCs through immunofluorescence staining, stem cell sphere assays and so forth in vitro. In vivo,… More >
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