Waraporn Saentaweesuk*†‡, Norie Araki‡, Kulthida Vaeteewoottacharn*†, Atit Silsirivanit*†‡, Wunchana Seubwai†§, Chutima Talabnin¶, Kanha Muisuk§, Banchob Sripa†#, Sopit Wongkham*†, Seiji Okada**, Chaisiri Wongkham*†
Oncology Research, Vol.26, No.4, pp. 605-616, 2018, DOI:10.3727/096504017X15009778205068
Abstract Cholangiocarcinoma (CCA) is a highly metastatic tumor, and the majority of patients with CCA have a short
survival time because there are no available effective treatments. Hence, a better understanding regarding CCA
metastasis may provide an opportunity to improve the strategies for treatment. A comparison study between the
highly metastatic cells and their parental cells is an approach to uncover the molecular mechanisms underlying
the metastatic process. In the present study, a lung metastatic CCA cell line, KKU-214L5, was established by
the in vivo selection of the tail vein-injected mouse model. KKU-214L5 cells possessed mesenchymal… More >
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