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  • Open Access


    Genipin Cross-linked Boron Doped Hydrogels: Evaluation of Biological Activities


    Journal of Polymer Materials, Vol.38, No.3-4, pp. 231-245, 2021, DOI:10.32381/JPM.2021.38.3-4.5

    Abstract Genipin cross-linked/boron doped starch/polyvinily alcohol (PVA) based hydrogel (SH-GNP-B) was synthesized as a new material having antimicrobial and antioxidant activity. The prepared hydrogel was characterized by X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) methods and evaluated for in vitro antimicrobial activities against selected organisms by disc diffusion tests. The antioxidant activity of the prepared hydrogels was evaluated using 2,2-diphenyl-1- picrylhydrazyl radical scavenging assays. Swelling behavior of the hydrogel was also investigated. The synthesized hydrogel was thermally stable and showed pH independent swelling tendency. SH-GNP-B hydrogel More >

  • Open Access


    In Vitro and in Silico Insights on the Biological Activities, Phenolic Compounds Composition of Hypericum perforatum L. Hairy Root Cultures

    Oliver Tusevski1,*, Marija Todorovska1, Jasmina Petreska Stanoeva2, Marina Stefova2, Sonja Gadzovska Simic1

    Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 921-941, 2023, DOI:10.32604/phyton.2023.024995

    Abstract Three Hypericum perforatum hairy root lines (HR B, HR F and HR H) along with non-transformed roots were analyzed for phenolic compounds composition and in vitro enzyme inhibitory properties. In silico molecular modeling was performed to predict the interactions of the most representative phenolic compounds in HR clones with enzymes related to depression, neurodegeneration and diabetes. Chromatographic analyses revealed that HR clones represent an efficient source of quinic acid and hydroxybenzoic acids, epicatechin and procyanidin derivatives, quercetin and kaempferol glycosides, as well numerous xanthones. In vitro antidepressant activity of HR extracts through monoamine oxidase A (MAO-A) inhibition was attributed… More >

  • Open Access


    Comparison of Essential Oil Composition, Phenolic Compound and Biological Activities of Salvia microphylla and Teucrium polium (Lamiaceae)

    Ayda Khadhri1, Chedia Aouadhi2, Eric Masson3, Antonio Pizzi4,5,*

    Journal of Renewable Materials, Vol.10, No.6, pp. 1607-1621, 2022, DOI:10.32604/jrm.2022.018950

    Abstract Salvia microphylla and Teucrium polium are medicinal and aromatic plants with ethnobotanical uses. The present study was conducted to investigate the chemical composition of Salvia microphylla and Teucrium polium essential oils, the secondary metabolites, and the biological activities of their infusion and methanolic (MeOH) extracts. Essential oils were extracted by hydrodistillation from shoots Salvia microphylla and Teucrium polium. Phenolic content, antioxidant and antimicrobial activities were determined. Gas chromatography-mass spectrometry (GC-MS) results showed the presence of significant qualitative and quantitative variations for the composition of the both essential oils (EO). Salvia microphylla EO were most complex and present 70 compounds with the major… More >

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