VERA KOLYOVSKA1,#, SONYA IVANOVA2, DESISLAVA DRENSKA3, DIMITAR MASLAROV3,4,#, RENETA TOSHKOVA1,*
BIOCELL, Vol.45, No.6, pp. 1485-1494, 2021, DOI:10.32604/biocell.2021.016250
Abstract Glycosphingolipids (gangliosides) have been characterized as important biological molecules with a key role as
regulators in many physiological processes on cellular, tissue, organ, and organism levels. The deviations in their normal
amounts, production, and metabolism are very often related to the development of many multi-factor socially important
diseases. GM3 ganglioside, as a small molecule, plays important roles in the cascade regulatory pathways in the pathology
of many disorders like neurodegenerative diseases, autoimmune diseases, inflammation, diabetes, malignant
transformation, and others. Ganglioside GM3 and its derivatives are membrane-bound glycosphingolipids composed
of an oligosaccharide head structure containing one sialic acid residue. These molecules… More >
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