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  • Open Access

    VIEWPOINT

    The versatility of mesenchymal stem cells: From regenerative medicine to COVID, what is next?

    THAÍS CASAGRANDE PAIM, MÁRCIA ROSÂNGELA WINK*

    BIOCELL, Vol.46, No.4, pp. 913-922, 2022, DOI:10.32604/biocell.2022.018498

    Abstract Mesenchymal stem cells (MSCs) play key roles in regenerative medicine by promoting tissue healing. MSCs can be isolated from different adult tissues and they are able to differentiate into several lineages. Due to their anti-inflammatory, angiogenic and immune-modulatory properties, MSCs are suitable for tissue engineering applications and, when associated with biomaterials, their benefits can be improved. Moreover, recently, MSCs have been studied for new clinical applications, such as in the treatment of patients with COVID-19. MSCs regenerative potential has been attributed to their secretome, which comprises extracellular matrix, soluble proteins and several elements, including the release of extracellular vesicles. Even… More >

  • Open Access

    REVIEW

    Potential Economic Value of Chitin and Its Derivatives as Major Biomaterials of Seafood Waste, with Particular Reference to Southeast Asia

    Hsiao Wei Tan1, Zhi Yin Joan Lim2, Nur Airina Muhamad3, Fong Fong Liew4,*

    Journal of Renewable Materials, Vol.10, No.4, pp. 909-938, 2022, DOI:10.32604/jrm.2022.018183

    Abstract With a growing population, changes in consumerism behavior and trends in consumption in Indo-Pacific Asia, our seafood processing and consumption practices produce a large volume of waste products. There are several advantages in regulating and sustaining shellfish processing industries. The major advantage of waste management is that it leads to better conservation of natural resources in the long run. Shrimp shell waste contains useful biomaterials, which are still untapped due to inadequate waste disposal and solid waste management. Chitin, the major component of shell waste, can be extracted either chemically or biologically. The chemical extraction approaches, which use acids and… More > Graphic Abstract

    Potential Economic Value of Chitin and Its Derivatives as Major Biomaterials of Seafood Waste, with Particular Reference to Southeast Asia

  • Open Access

    ARTICLE

    Composite Biomaterials Based on Poly(L-Lactic Acid) and Functionalized Cellulose Nanocrystals

    Mariia Stepanova1, Ilia Averianov1, Olga Solomakha1, Natalia Zabolotnykh2, Iosif Gofman1, Mikhail Serdobintsev2, Tatiana Vinogradova2, Viktor Korzhikov-Vlakh1,3, Evgenia Korzhikova-Vlakh1,3,*

    Journal of Renewable Materials, Vol.8, No.4, pp. 383-395, 2020, DOI:10.32604/jrm.2020.09206

    Abstract The biocomposite films were prepared from poly(L-lactic acid) and cellulose nanocrystals. To improve interfacial compatibility of hydrophilic cellulose nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties, cellulose was functionalized with poly(glutamic acid). The modified cellulose nanocrystals were better distributed and less aggregated within the matrix, which was testified by scanning electron, optical and polarized light microscopy. According to mechanical tests, composites filled with nanocrystals modified with PGlu demonstrated higher values of Young’s modulus, elongation at break and tensile strength. Incubation of composite materials in model buffer solutions for 30 weeks followed with staining of Ca2+More >

  • Open Access

    ABSTRACT

  • Open Access

    ABSTRACT

  • Open Access

    ABSTRACT

    Recent Progress in Medical Biomaterials

    Qiqing Zhang1,2,3,*, Yuan Zhang4, Linzhao Wang4, Yongzhen Xing4

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 134-135, 2019, DOI:10.32604/mcb.2019.07301

    Abstract Guided tissue regeneration (GTR) is a technique that selectively guides cells to attach and proliferate towards an injured site to achieve tissue regeneration through a physical barrier membrane. In this review, we presented a brief overview of the development of GTR technology and GTR materials. Nowadays, new technologies such as electrospinning, nanotechnology, controlled release technique, and 3D printing have been introduced into the study of GTR materials. Resorbable membrane as GTR materials are available as alternatives to conventional non-resorbable membranes. Current GTR materials not only act as a physical barrier membrane but also as a scaffold to play a role… More >

  • Open Access

    ARTICLE

    Elaboration of Materials with Functionality Gradients by Assembly of Chitosan-Collagen Microspheres Produced by Microfluidics

    David Azria1,2, Raluca Guermache1,2, Sophie Raisin1, Sébastien Blanquer1, Frédéric Gobeaux3, Marie Morille1, Emmanuel Belamie1,2,*

    Journal of Renewable Materials, Vol.6, No.3, pp. 314-324, 2018, DOI:10.7569/JRM.2017.634186

    Abstract Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications, among which are their hydrophilicity, biocompatibility and biodegradability. In many cases, functional recovery of an injured tissue or organ requires oriented cell outgrowth, which is particularly critical for nerve regeneration. Therefore, there is a growing interest for the elaboration of materials exhibiting functionalization gradients able to guide cells. Here, we explore an original way of elaborating such gradients by assembling particles from a library of functionalized microspheres. We propose a simple process to prepare chitosan-collagen hybrid microspheres by… More >

  • Open Access

    ARTICLE

    Studies on Bone-Derived Calcium Phosphate Materials

    Agnieszka Sobczak-Kupiec1, Klaudia Pluta1, Dagmara Malina1*, Bożena Tyliszczak2

    Journal of Renewable Materials, Vol.5, No.3-4, pp. 180-188, 2017, DOI:10.7569/JRM.2017.634106

    Abstract In recent years, the development of composite biomaterials has been the subject of very intensive research. The elaboration of technology for manufacturing new biomaterials will allow their practical implementation and adaptation to changing market needs. One of the key components in the developed composite materials will be natural origin hydroxyapatite (HAp) and tricalcium phosphate (TCP) obtained from bone products. In this study, preparation and detailed characterization of bone-derived calcium phosphates as a component of biomaterial composites is proposed. This novel method of obtaining hydroxyapatite for biomedical applications allows the obtainment of a material with expected parameters. In this study, pork… More >

  • Open Access

    ARTICLE

    Viscoelasticity of Living Materials: Mechanics and Chemistry of Muscle as an Active Macromolecular System

    Hong Qian*

    Molecular & Cellular Biomechanics, Vol.5, No.2, pp. 107-118, 2008, DOI:10.3970/mcb.2008.005.107

    Abstract At the molecular and cellular level, mechanics and chemistry are two aspects of the same macromolecular system. We present a bottom-up approach to such systems based on Kramers' diffusion theory of chemical reactions, the theory of polymer dynamics, and the recently developed models for molecular motors. Using muscle as an example, we develop a viscoelastic theory of muscle in terms of an simple equation for single motor protein movement. Both A.V. Hill's contractile component and A.F. Huxley's equation of sliding-filament motion are shown to be special cases of the general viscoelastic theory of the active material. Some disparity between the… More >

  • Open Access

    ARTICLE

    Computational Modelling of Isotropic Multiplicative Growth

    G. Himpel, E. Kuhl, A. Menzel, P. Steinmann1

    CMES-Computer Modeling in Engineering & Sciences, Vol.8, No.2, pp. 119-134, 2005, DOI:10.3970/cmes.2005.008.119

    Abstract The changing mass of biomaterials can either be modelled at the constitutive level or at the kinematic level. This contribution attends on the description of growth at the kinematic level. The deformation gradient will be multiplicatively split into a growth part and an elastic part. Hence, in addition to the material and the spatial configuration, we consider an intermediate configuration or grown configuration without any elastic deformations. With such an ansatz at hand, contrary to the modelling of mass changes at the constitutive level, both a change in density and a change in volume can be modelled. The algorithmic realisation… More >

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