MASSIMO CONESE1,*, AURELIO PORTINCASA2
BIOCELL, Vol.46, No.8, pp. 1815-1826, 2022, DOI:10.32604/biocell.2022.019448
Abstract The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective.
Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especially
exosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition,
and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand,
biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular
matrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels,
and MSC-derived exosomes constructed for cutaneous wound healing. Studies demonstrate that there… More >
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