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    Design and development of a dual-flow bioreactor mimicking intestinal peristalsis and permeability in epithelial tissue barriers for drug transport assessment

    Odin RAMÍREZ-FERNÁNDEZ1,2,3,*, Ludovika CACOPARDO1, Benjamín LEON-MANCILLA2, Joana COSTA1

    BIOCELL, Vol.43, No.1, pp. 29-36, 2019, DOI:10.32604/biocell.2019.04790

    Abstract We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed presents a semipermeable membrane bioreactor, with peristaltic flow and compression variation that allows adjustment of luminal flow rate. In addition, this system is also capable of achieving the drug distribution in the small intestine model from the apical compartment to the basal compartment by the semipermeable channel. This dynamic bioreactor can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy More >

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