Odin RAMÍREZ-FERNÁNDEZ1,2,3,*, Ludovika CACOPARDO1, Benjamín LEON-MANCILLA2, Joana COSTA1
BIOCELL, Vol.43, No.1, pp. 29-36, 2019, DOI:10.32604/biocell.2019.04790
Abstract We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic
nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed
presents a semipermeable membrane bioreactor, with peristaltic flow and compression variation that allows adjustment
of luminal flow rate. In addition, this system is also capable of achieving the drug distribution in the small intestine
model from the apical compartment to the basal compartment by the semipermeable channel. This dynamic bioreactor
can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy with
the previously described in… More >
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