MAYSON H. ALKHATIB1,2,*, SALWA M. AL-HASHEMI1, HANA M. GASHLAN1
BIOCELL, Vol.45, No.3, pp. 695-703, 2021, DOI:10.32604/biocell.2021.014349
Abstract Incorporation of etoposide (ETP) into nanoemulsion (NE) containing polyunsaturated fatty acids (PUFAs) may
potentially augment its antiproliferation effect on the cancer cells. The current study aimed to examine the in vitro antitumor
activity of a novel formulation (ETP-BC/EP-NE) produced by combining the anticancer drug (ETP) with NE (BC/EP-NE)
consisting of the black currant seed and organic evening primrose oils. The produced formulas were physically characterized
using zetasizer measurements. Their cytotoxic effect was testified at concentrations ranges from 0.0001 to 5 μM using
CCK-8. Apoptotic and anti-invasion effects were evaluated using the assays of mitochondrial membrane potential,
annexin V-FITC double staining,… More >
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