Jie Zhong1,#, Li Deng2,#, Yu Jiang3, Lianhong Zou3, Huabing Yuan4, Shuang-xiang Tan1,*
BIOCELL, Vol.42, No.3, pp. 99-104, 2018, DOI:10.32604/biocell.2018.04915
Abstract This study aimed to determine the effects of black tea polyphenols on gene expression in hepatocellular
cancer cells. The total RNA from HepG2 hepatocellular cancer cells treated with black tea polyphenols was subjected to
Human 14K cDNA microarray analysis. Real-time PCR and Western blot analysis were conducted to verify microarray
data. Black tea polyphenols treatment at the dose of 20 mg/L, 40 mg/L or 80 mg/L for one to three days inhibited the
growth of HepG2 cells in a dose and time dependent manner. A total of 48 genes showed more than two-fold change
after black tea polyphenols treatment, including… More >
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