NERGIZ HACER TURGUT1,*, HUSEYIN GUNGOR2, MEHMET EKICI3, MUMIN ALPER ERDOGAN4, MEHMET ONDER KARAYIGIT5, HAKI KARA2
BIOCELL, Vol.46, No.9, pp. 2111-2122, 2022, DOI:10.32604/biocell.2022.020383
Abstract Side effects of cisplatin, especially dose-dependent nephrotoxicity, are major factors limiting its use in cancer.
Boldine ((S)-2, 9-dihydroxy-1, 10-dimethoxy-aporphine) is a natural alkaloid known for its strong antioxidant activity
present in leaves/bark of boldo tree (Peumus boldus Molina), a native tree in Chile. Here, we aimed to investigate the
nephroprotective effect of boldine and its underlying mechanisms on cisplatin-induced rat renal injury. Thirty Wistar
albino rats divided into 5 groups (Control, Cis, Bold.40, Cis + Bold.20, Cis + Bold.40 groups) were used. Rats received
boldine (20 or 40 mg/kg/day), or vehicle (saline) intraperitoneal for 14 days and a single dose… More >
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