JAMES L. ROSENBERG1, WILLIAM WOOLLEY1, IHSAN ELNUNU1, JULIA KAMML2, DAVID S. KAMMER2, CLAIRE ACEVEDO1,3,*
BIOCELL, Vol.47, No.7, pp. 1651-1659, 2023, DOI:10.32604/biocell.2023.028014
Abstract Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen, leading to the accumulation of advanced glycation end-products (AGEs) cross-links in collagenous tissues. More recently, AGEs content has been related to loss of bone quality, independent of bone mass, and increased fracture risk with aging and diabetes. Loss of bone quality is mostly attributed to changes in material properties, structural organization, or cellular remodeling. Though all these factors play a role in bone fragility disease, some common recurring patterns can be found between diabetic and age-related bone fragility. The main pattern we will discuss… More >
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