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    Significant association of a single nucleotide polymorphism in the upstream region of FGFR1OP2/wit3.0 gene with residual ridge resorption of mandible in Saudis

    Sahar ALZAIN1, Hana AL SHEIKH1, Arwa AL THOMALI2, Fatimah AL-MUKAYNIZI2, Noha ALMOBEREK2, Sahar A. ALMALKI2, Narasimha Reddy PARINE3, Arjumand WARSY2,

    BIOCELL, Vol.44, No.1, pp. 55-62, 2020, DOI:10.32604/biocell.2020.07974

    Abstract Residual ridge resorption (RRR) is the decrease in the jaw structure that follows tooth extraction. It is a multifactorial disorder, but reports on the associated genetic factors are scarce, particularly amongst the Saudis. This study aimed to investigate the role of single nucleotide polymorphisms (SNPs) in fibroblast growth factor receptor 1 oncogene partner 2 (FGFR1OP2) in RRR development in Saudis. The study included 192 individuals (RRR = 96; controls = 96) attending outpatient clinics at the College of Dentistry, King Saud University. Demographic and clinical data were collected, the digital panoramic dental radiograph was obtained, and mandibular residual ridge height… More >

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