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    ARTICLE

    Extracting Sub-Networks from Brain Functional Network Using Graph Regularized Nonnegative Matrix Factorization

    Zhuqing Jiao1, *, Yixin Ji1, Tingxuan Jiao1, Shuihua Wang2, *

    CMES-Computer Modeling in Engineering & Sciences, Vol.123, No.2, pp. 845-871, 2020, DOI:10.32604/cmes.2020.08999

    Abstract Currently, functional connectomes constructed from neuroimaging data have emerged as a powerful tool in identifying brain disorders. If one brain disease just manifests as some cognitive dysfunction, it means that the disease may affect some local connectivity in the brain functional network. That is, there are functional abnormalities in the sub-network. Therefore, it is crucial to accurately identify them in pathological diagnosis. To solve these problems, we proposed a sub-network extraction method based on graph regularization nonnegative matrix factorization (GNMF). The dynamic functional networks of normal subjects and early mild cognitive impairment (eMCI) subjects were vectorized and the functional connection… More >

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