SARA SOLTANIAN1, HELIA RIAHIRAD1, ATHAREH PABARJA1, MOHAMMAD REZA KARIMZADEH2, KOLSOUM SAEIDI3,4
BIOCELL, Vol.41, No.2-3, pp. 33-40, 2017, DOI:10.32604/biocell.2017.41.033
Abstract Cancer stem cells (CSCs) are a small subpopulation of cancer cells whose resistance to
chemotherapy and radiotherapy plays a pivotal role in treatment failure, tumor recurrence and metastasis.
Today, the ability of many phytochemicals in targeting of CSCs has been identified. Kaempferol is a plant
phytoestrogen that was recognized as a useful agent for targeting cancer cells by apoptosis induction,
cell cycle arrest and inhibition of angiogenesis, migration, and invasion of cancer cells. In this study,
we compared the effect of docetaxel as a common breast cancer chemotherapy drug and kaempferol
on MCF-7 breast CSCs. Results showed that both docetaxel… More >
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