ISIDORA PETROVIC1, MILENA MILIVOJEVIC1, ANA ARSENIJEVIC2, ANDRIJANA LAZIC1, NATASA KOVACEVIC GRUJICIC1, MARIJA SCHWIRTLICH1, JELENA POPOVIC3, MILENA STEVANOVIC1,4,5,*
BIOCELL, Vol.45, No.5, pp. 1355-1367, 2021, DOI:10.32604/biocell.2021.015817
Abstract Genetic and molecular heterogeneity, together with intrinsic and acquired resistance to therapy, represent the
major obstacles to the successful treatment of different types of breast carcinoma. Increasing evidence demonstrates that
SOX transcription factors in breast carcinomas could act both as oncogenes and tumor suppressors and have been
associated with tumor stage and grade, poor prognosis, and therapy resistance. Both SOX2 and SOX18 overexpression has been correlated with poor prognosis in breast carcinomas, and these genes are recognized as potential
antitumor targets. Our aim was to evaluate the effect of retinoic acid (RA), a well-known cyto-differentiating agent,
on breast carcinoma cells… More >
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