Bingbing ZHANG1, 2, Ying ZHANG1, 2, Xiaomei ZHANG1, 2, Yonggang LV1, 2
BIOCELL, Vol.42, No.1, pp. 17-24, 2018, DOI:10.32604/biocell.2018.06115
Abstract Mechanical microenvironment can strongly affect the metastatic efficiency of circulating
tumor cells. However, the effect of suspension state on their extravasation and the mechanisms involved
are still unclear. To explore the influence of suspension state on extravasation (including adhesion,
spreading and transendothelial migration) of breast tumor cells and its relevant molecular mechanism,
MDA-MB-231 cells were cultured on poly (2-hydroxyethyl methacrylate) coated 6-well plates to minic
the suspension state. Suspension state promoted adhesion, spreading and transendothelial migration
of MDA-MB-231 cells to EAhy926 endothelial cells (ECs) monolayer under both the static condition
and 0.5 dyne/cm2
flow shear stress (FSS). The number of… More >
Login
Register
