YOUYANG HU1,#, YISHU LUO1,#, TIANYUE XIE1, YUEHUA CHEN1,2, JUN ZHAO1, WEICHAO JI3, ZHIWEI YAN3, SITONG QIU3, KEXIN GAO3, HAIXIA ZHU4, LIMIN MA1,*, QIYOU YIN1,*
Oncology Research, Vol.33, No.7, pp. 1695-1708, 2025, DOI:10.32604/or.2025.060021
- 26 June 2025
Abstract Objective: Neuroblastoma (NB) is frequently associated with high-risk pediatric cases that demonstrate limited response to cisplatin, contributing to a poor prognosis. Recent studies have explored the role of tumor cell senescence in increasing sensitivity to this chemotherapy agent. This study aims to identify genes related to cell senescence in children diagnosed with NB, evaluate their influence on cisplatin sensitivity, and investigate potential strategies to enhance the efficacy of chemotherapy. Methods: Gene expression profiles and clinical data were obtained for 498 NB patients from the GEO database (GSE49710). The study focused on identifying genes that were… More >
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