YUSEN ZHANG1,2,3, LIPING LIU1,2,3, BIWEI LUO1,2,3, HONGGUI TANG1,2,3, XIAOFANG YU1,2,3, SHIYUN BAO1,2,3,*
Oncology Research, Vol.31, No.3, pp. 317-331, 2023, DOI:10.32604/or.2023.028418
Abstract Background: Cholangiocarcinoma (CCA) represents the epithelial cell cancer with high aggressiveness whose
five-year survival rate is poor with standard treatment. Calcyclin-binding protein (CACYBP) shows aberrant expression
within several malignant tumors, but the role of CACYBP in CCA remains unknown. Methods: Immunohistochemical
(IHC) analysis was used to identify CACYBP overexpression in clinical samples of CCA patients. Moreover, its
correlation with clinical outcome was revealed. Furthermore, CACYBP’s effect on CCA cell growth and invasion was
investigated in vitro and in vivo using loss-of-function experiments. Results: CACYBP showed up-regulation in CCA,
which predicts the dismal prognostic outcome. CACYBP had an important effect on… More >
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