QIUQIANG CHEN1,*, XUEJUN GUO2, WENXUE MA3,*
Oncology Research, Vol.32, No.1, pp. 49-60, 2024, DOI:10.32604/or.2023.042383
Abstract Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor
microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein,
has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However,
the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain
incompletely understood. This comprehensive review aims to provide an overview of CD47’s multifaced role in TME
regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including
checkpoint inhibitors and… More >
Graphic Abstract
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