HONGMIN CAO1,#,*, YING XUE2,#, FEI WANG1, GUANGYAO LI1, YULAN ZHEN1, JINGWEN GUO1
BIOCELL, Vol.48, No.3, pp. 473-490, 2024, DOI:10.32604/biocell.2024.048946
Abstract Background: Cytotoxic T lymphocytes (CD8+ T) cells function critically in mediating anti-tumor immune response in cancer patients. Characterizing the specific functions of CD8+ T cells in lung adenocarcinoma (LUAD) could help better understand local anti-tumor immune responses and estimate the effect of immunotherapy. Methods: Gens related to CD8+ T cells were identified by cluster analysis based on the single-cell sequencing data of three LUAD tissues and their paired normal tissues. Weighted gene co-expression network analysis (WGCNA), consensus clustering, differential expression analysis, least absolute shrinkage and selection operator (LASSO) and Cox regression analysis were conducted to classify molecular subtypes for LUAD… More >
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