RUYU YAN1,#, JUNJIE WANG1,#, MINXIA LIU2, KECHENG ZHOU1,3,*
BIOCELL, Vol.46, No.10, pp. 2159-2165, 2022, DOI:10.32604/biocell.2022.021107
Abstract Emerging cohorts and basic studies have associated certain genetic modifications in cancer patients, such as gene
mutation, amplification, or deletion, with the overall survival prognosis, underscoring patients’ genetic background may
directly regulate drug sensitivity/resistance during chemotherapies. Understanding the molecular mechanism
underpinning drug sensitivity/resistance and further uncovering the effective drugs have been the major ambition in the
cancer drug discovery. The emergence and popularity of CRISPR/Cas9 technology have reformed the entire life science
research, providing a precise and simplified genome editing tool with unlimited editing possibilities. Furthermore, it
presents a powerful tool in cancer drug discovery, which hopefully facilitates us with… More >
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