Mengdan Ma1,2, Yuchen Liu1,*, Weiren Huang1,*
Oncologie, Vol.23, No.4, pp. 463-492, 2021, DOI:10.32604/oncologie.2022.019415
Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, which is an RNA-guided
nuclease system, plays an important role in the adaptive immune response of bacteria, and it is a rapidly developing gene editing technology. It has been widely used in a variety of cells, microorganisms, plants, and animals.
This technique has helped to overcome the limitations of previous gene editing methods, and it has promoted the
development of synthetic biology, genetics, and proteomics. The ability of the CRISPR-Cas system to modify the
genetic components of a system has led to various practical applications, such as base editing, transcription regulation,… More >
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