Xue-Yi Yang, Ye Sheng
Oncology Research, Vol.27, No.9, pp. 997-1006, 2019, DOI:10.3727/096504018X15439207752093
Abstract Although miR-101 is involved in the development and progression of T-cell acute lymphoblastic leukemia
(T-ALL), the underlying molecular mechanisms remain unclear. In this article, we report that miR-101 expression was inversely correlated with CX chemokine receptor 7 (CXCR7) level in T-ALL. Introducing miR-101
inhibited T-ALL cell proliferation and invasion in vitro and suppressed tumor growth and lung metastasis in
vivo. CXCR7 was identified as a direct target of miR-101. The inhibitory effects of miR-101 were mimicked
and counteracted by CXCR7 depletion and overexpression, respectively. Mechanistically, miR-101 targets
CXCR7/STAT3 axis to reduce T-ALL growth and metastasis. Overall, these findings implied the… More >
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