XINYAN CHEN1,2, HAIXIA ZHANG1,2, LIN LI1,2,*
BIOCELL, Vol.45, No.4, pp. 1023-1032, 2021, DOI:10.32604/biocell.2021.014873
Abstract Corneal collagen crosslinking (CXL) has revolutionized the treatment of keratoconus in the past decade. In
order to evaluate the 3-month effects of CXL on corneal fibroblasts, a longitudinal study at the tissue and cellular
level was carried out with a total of 16 rabbits that underwent CXL, deepithelialization (DEP), or non-treatment
(control) and kept for 1 to 3 months. The duration of corneal stromal remodeling after CXL was determined by
examining the differentiation, apoptosis, and number changes of keratocytes in tissue sections from animals 1, 2, or 3
months post-treatment. Upon the finish of tissue remodeling, separate rabbits were used… More >
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