AASTHA MITTAL1, NEELAM MAHALA1, KOWTHAVARAPU VENKATA KRISHNA2, UMA S. DUBEY1,*, SUNIL KUMAR DUBEY2,3,*
BIOCELL, Vol.46, No.1, pp. 127-136, 2022, DOI:10.32604/biocell.2021.015932
Abstract Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral
bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles as a drug
delivery system. Camel milk casein is not only biocompatible on oral administration but is actually a dietary protein of
pharmaceutical relevance. Casein is used because of its amphiphilic nature, self-assembling property, ability to show
sustained release, and capability of encapsulating both hydrophilic and hydrophobic drugs. In this study, camel milk
casein nanoparticles loaded with sorafenib were developed and characterized. Characterization of casein nanoparticles
was done by dynamic… More >
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