PATRIC HAMBLETON1, MANUEL ALEJANDRO BARBIERI1,2,3,4,*
BIOCELL, Vol.44, No.4, pp. 525-534, 2020, DOI:10.32604/biocell.2020.011407
Abstract Cancerous cells display abnormalities in the signal transduction pathways responsible for responding to
extracellular growth factors, or mitogens. Mutations that alter proteins involved in these types of pathways can
lead to inappropriate or unregulated cell growth, and therefore predispose the cell to become malignant. The
critical role of the Ras/mitogen-activated protein kinase (MAPK) pathway in transducing growth signals to the
interior of the cell and subsequently stimulating cell growth and proliferation is underscored by the fact that
roughly one quarter of all human tumors contain mutant forms of Ras proteins. A particular focus on the
signaling and membrane trafficking adaptor… More >
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