Wendong Jia^#, Ting Zhang^#, Ziying Zhang, Lingzhi Wu, Xihao Fu, Zhenxin Wang^*, Ni Yin^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068651 - 30 December 2025

Abstract Objectives: Chromobox 4 (CBX4), a polycomb protein family member linked to tumor pathogenesis via dysregulation, has an incompletely defined role in gastric cancer (GC). The study aimed to investigate the role and mechanism of CBX4 in GC progression and evaluate its potential as a therapeutic target. Methods: CBX4 expression was assessed in GC tissues vs. adjacent non-cancerous tissues and in GC cell lines vs. normal gastric mucosal epithelial cells. Clinicopathological correlations were analyzed. Functional impacts of CBX4 were determined using knockdown and overexpression models in vitro (cell proliferation, migration, invasion) and in vivo (xenograft tumorigenesis in nude… More >

Xiaopan Zou^1,2, Meiyang Sun³, Xin Jiang¹, Jingze Yu², Xiaomeng Li^4,*, Bingyu Nie^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.066662 - 30 December 2025

Abstract Objective: Triple-negative breast cancer (TNBC) is highly aggressive and lacks an effective targeted therapy. This study aimed to elucidate the functions and possible mechanisms of action of zinc finger miz-type containing 2 (ZMIZ2) and minichromosome maintenance complex component 3 (MCM3) in TNBC progression. Methods: The relationship between ZMIZ2 expression and clinical characteristics of TNBC was investigated. In vitro and in vivo experiments were performed to investigate the role of ZMIZ2 dysregulation in TNBC cell malignant behaviors. The regulatory relationship between ZMIZ2 and MCM3 was also explored. Transcriptome sequencing was performed to elucidate possible mechanisms underlying the ZMIZ2/MCM3… More >

David Amilo^1,*, Khadijeh Sadri¹, Evren Hincal^1,2, Mohamed Hafez^3,4

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2189-2222, 2025, DOI:10.32604/cmes.2025.070298 - 26 November 2025

Abstract Breast cancer’s heterogeneous progression demands innovative tools for accurate prediction. We present a hybrid framework that integrates machine learning (ML) and fractional-order dynamics to predict tumor growth across diagnostic and temporal scales. On the Wisconsin Diagnostic Breast Cancer dataset, seven ML algorithms were evaluated, with deep neural networks (DNNs) achieving the highest accuracy (97.72%). Key morphological features (area, radius, texture, and concavity) were identified as top malignancy predictors, aligning with clinical intuition. Beyond static classification, we developed a fractional-order dynamical model using Caputo derivatives to capture memory-driven tumor progression. The model revealed clinically interpretable patterns: More >

Sihai Duan^1,2,#, Xiaoyan Li^3,#, Cailu Song³, Song Wu³, Yunyun Tang^3,4, Qing Bao^3,4, Na Li^3,*, Hailin Tang^3,*

Oncology Research, Vol.33, No.11, pp. 3543-3556, 2025, DOI:10.32604/or.2025.068292 - 22 October 2025

Abstract Objectives: Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest prognosis. This study aimed to elucidate the molecular pathways through which isoliquiritigenin (ISL), a natural chalcone compound derived from licorice and other plant roots, targets interferon regulatory factor 5 (IRF5) in TNBC. Methods: TNBC cell lines were cultured and subjected to IRF5 knockdown using short hairpin RNA. Cell proliferation was assessed by cell counting kit-8 (CCK-8) assay and colony formation assays. Western blotting and quantitative reverse transcription polymerase chain reaction (RT-PCR) were employed to measure expression levels of IRF5, solute carrier family… More >

Botao Pan¹, Zirun Luo², Xiujuan Yang¹, Qingqing Liu³, Zhimin Yang^4,*, Chenglai Xia^1,3,*

Oncology Research, Vol.33, No.11, pp. 3557-3582, 2025, DOI:10.32604/or.2025.068119 - 22 October 2025

Abstract Objectives: Breast cancer is characterized by significant metabolic dysregulation, in which altered enzyme activity plays a central role. Malate dehydrogenase 2 (MDH2), a key enzyme in the tricarboxylic acid cycle, has been implicated in several malignancies, but its role in breast cancer tumorigenesis and progression remains unclear. We aimed to elucidate the oncogenic role of MDH2 in breast cancer and to evaluate its potential as a diagnostic, therapeutic, and prognostic biomarker. Methods: We combined in vitro cell-based assays with mouse xenograft models to systematically dissect how MDH2 governs breast cancer growth. In vitro, we assessed the effects… More >

Yun Zhou^1,2, Shixiong Liu^1,2, Ya Zheng^1,3,4, Yuping Wang^1,3,4,*, Yongning Zhou^1,3,4,*

BIOCELL, Vol.49, No.10, pp. 1967-1983, 2025, DOI:10.32604/biocell.2025.069869 - 22 October 2025

Abstract Background: Gastric cancer (GC) is a prevalent cause of death. 3,9-Di-O-methylnissolin (DOM) is a flavonoid isolated from Astragalus membranaceus. It has anticancer and anti-inflammatory effects, but its effect and mechanism of action on GC are not very clear. Methods: The appropriate concentration was selected after observing the effects of varying concentrations of DOM on the viability of GC cells, which was examined through the cell counting kit-8 (CCK-8) assay. The receptor-interacting protein kinase 2 (RIPK2) overexpression plasmid was transfected into GC cells, which were then treated with DOM. Cell cycle and proliferation, RIPK2 levels, and inflammatory… More > Graphic Abstract

Wenjing Liao^1,#, Liaodi Wang^2,#, Zhen Huang¹, Ziyu Zou¹, Yimin Liu¹, Haoyue Liu¹, Zhaoning Duan¹, Liangdan Tang^1,*

Oncology Research, Vol.33, No.10, pp. 3041-3064, 2025, DOI:10.32604/or.2025.065451 - 26 September 2025

Abstract Objectives: Ovarian cancer (OC) is a highly heterogeneous disease characterized by high metastatic potential and frequent recurrence. 3β-hydroxysterol Δ24-reductase (DHCR24) is closely associated with the progression of various malignant tumors, but its role in OC remains unexplored. This study is the first to systematically investigate the function of DHCR24 in OC and elucidate its mechanism in promoting OC progression, providing novel theoretical insights for targeted therapy. Methods: The expression of DHCR24 was evaluated in tissues using bioinformatics and clinical data; the impact of DHCR24 on the malignant behavior of OC was assessed through in vivo and in… More >

Chi Zhang^1,#, Xi Huang^2,#, Cheng Hu¹, Bowen Tang¹, Jianjie Wu¹, Zhuolun Sun¹, Weian Zhu¹, Xiangfu Zhou¹, Hengjun Xiao^1,*, Hua Wang^1,*

Oncology Research, Vol.33, No.9, pp. 2331-2351, 2025, DOI:10.32604/or.2025.065119 - 28 August 2025

Abstract Background: U2AF homology motif kinase 1 (UHMK1) has been associated with RNA processing and protein phosphorylation, thereby influencing tumor progression. The study aimed to explore its regulatory mechanisms and biological functions in human prostate cancer (PCa). Methods: In this study, we systematically evaluated the expression and prognostic significance of UHMK1 in public databases, followed by validation through immunohistochemistry (IHC) in PCa specimens. Both gain-of-function and loss-of-function experiments were conducted to elucidate the role of UHMK1 in vitro and in vivo. Additionally, a series of molecular and biochemical assays were performed to investigate the regulatory mechanisms underlying UHMK1… More >

Hailong Li^1,#, Wen Ouyang^2,#, Yiyin Long¹, Yun Peng¹, Ziyi Liu¹, Qi Zhou¹, Rong Xu^1,*, Wei Du^1,*

Oncology Research, Vol.33, No.9, pp. 2549-2571, 2025, DOI:10.32604/or.2025.065050 - 28 August 2025

Abstract Background: The study aimed to explore the clinical value of mitochondrial ribosomal protein L18 (MRPL18) in breast cancer. Methods: Multiple databases were used to validate the expression of MRPL18. The prognostic impact and predictive value of MRPL18 were evaluated by using predictive models. Protein-protein interaction (PPI) networks were constructed by using GeneMANIA. Enrichment analysis is used to explore the signaling pathway regulated by MRPL18. Cell counting kit-8 (CCK-8) assays, colony formation, migration assays, flow cytometry, and xenograft models were employed to evaluate the role of MRPL18 in tumor progression. The immune response of MRPL18 was More >

Yuhang Jiang^#, Yijun Xu^#, Qi Zhu, Yingxia Wu, Zhe Wang, Shuang He, Shiyong Yu^*, Honggang Xiang^*

Oncology Research, Vol.33, No.9, pp. 2379-2398, 2025, DOI:10.32604/or.2025.063501 - 28 August 2025

Abstract Background: Colorectal cancer (CRC) is common and deadly, often leading to metastasis, challenging treatment, and poor outcomes. Understanding its molecular basis is crucial for developing effective therapies. Aims: This study aimed to investigate the role of Myosin Heavy Chain 11 (MYH11) in CRC progression, especially its effects on epithelial-mesenchymal transition (EMT) and cell behavior, and to explore its potential regulation by the EMT transcription factor zinc finger E-box binding homeobox 1 (ZEB1). Methods: Differential expression analysis was performed in the GSE123390 and TCGA-READ datasets, and 317 intersection genes were identified. The hub gene MYH11 was identified… More >