Muath Awadalla^1,*, Kinda Abuasbeh¹, Yves Yannick Yameni Noupoue², Mohammed S. Abdo³

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.3, pp. 2767-2785, 2023, DOI:10.32604/cmes.2023.024036

Abstract This study focuses on the dynamics of drug concentration in the blood. In general, the concentration level of a drug in the blood is evaluated by the mean of an ordinary and first-order differential equation. More precisely, it is solved through an initial value problem. We proposed a new modeling technique for studying drug concentration in blood dynamics. This technique is based on two fractional derivatives, namely, Caputo and Caputo-Fabrizio derivatives. We first provided comprehensive and detailed proof of the existence of at least one solution to the problem; we later proved the uniqueness of the existing solution. The proof… More >

Ravi Shanker Dubey¹, Dumitru Baleanu^2,3, Manvendra Narayan Mishra^1,*, Pranay Goswami⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.3, pp. 1247-1263, 2021, DOI:10.32604/cmes.2021.015224

Abstract Diabetes is a burning issue in the whole world. It is the imbalance between body glucose and insulin. The study of this imbalance is very much needed from a research point of view. For this reason, Bergman gave an important model named-Bergman minimal model. In the present work, using Caputo-Fabrizio (CF) fractional derivative, we generalize Bergman’s minimal blood glucose-insulin model. Further, we modify the old model by including one more component known as diet D(t), which is also essential for the blood glucose model. We solve the modified model with the help of Sumudu transform and fixed-point iteration procedures. Also,… More >