MIZUNA YANO1, YUTA UMEHARA1, TOMOKAZU KUDO1, TAKAO NAKAMURA2, TADASHI KOSAWADA1, ATSUYOSHI NISHINA3, MASAKI SAZUKA4, DAISUKE SATO1,*, ZHONGGANG FENG1,*
BIOCELL, Vol.45, No.5, pp. 1213-1229, 2021, DOI:10.32604/biocell.2021.016281
Abstract While fatty acids play essential roles in the physiology of the myocardium, conventional culture media contain little lipid. We previously revealed that rat neonatal myocardium mainly contains docosahexaenoic (DHA), linoleic (LA), and arachidonic (AA) acids as polyunsaturated fatty acids (PUFAs), and these contents in cultured cardiomyocytes derived from fetal rats were markedly lower than those in the neonatal myocardium. In this study, we first assessed the effects of supplementation of DHA, LA, or AA on the fatty acid contents and the percentage change of contractile area in primarily cultured rat cardiomyocytes. Based on this assessment, we then evaluated the effects… More >
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