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    Topological Remodeling of Cultured Endothelial Cells by Characterized Cyclic Strains

    Nooshin Haghighipour, Mohammad Tafazzoli-Shadpour, Mohammad Ali Shokrgozar, Samira Amini, Amir Amanzadeh, Mohammad Taghi Khorasani

    Molecular & Cellular Biomechanics, Vol.4, No.4, pp. 189-200, 2007, DOI:10.3970/mcb.2007.004.189

    Abstract Evaluation of mechanical environment on cellular function is a major field of study in cellular engineering. Endothelial cells lining the entire vascular lumen are subjected to pulsatile blood pressure and flow. Mechanical stresses caused by such forces determine function of arteries and their remodeling. Critical values of mechanical stresses contribute to endothelial damage, plaque formation and atherosclerosis. A device to impose cyclic strain on cultured cells inside an incubator was designed and manufactured operating with different load amplitudes, frequencies, numbers of cycles and ratios of extension to relaxation. Endothelial cells cultured on collagen coated silicon… More >

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