Konstantinos A. Lazopoulos1, Dimitrije Stamenović2
Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 43-48, 2006, DOI:10.3970/mcb.2006.003.043
Abstract It is well documented that in response to substrate stretching adhering cells alter their orientation. Generally, the cells reorient away from the direction of the maximum substrate strain, depending upon the magnitude of the substrate strain and the state of cell contractility. Theoretical models from the literature can describe only some aspects of this phenomenon. In the present study, we developed a more comprehensive mathematical model of cell reorientation than the current models. Using the framework of theory of non-linear elasticity, we found that the problem of cell reorientation was a stability problem, with the global (Maxwell's) criterion for stability.… More >
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