Yang Song1, Jennifer Soto1, Song Li1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 92-92, 2019, DOI:10.32604/mcb.2019.07345
Abstract Cell reprograming technologies have broad applications in cell therapy, disease modeling and drug screening. Direct reprogramming of fibroblasts into induced neuronal (iN) cells has been achieved via the forced expression of three transcription factors: Ascl1, Brn2 and Myt1l. Accumulative evidence suggests that biophysical factors in the microenvironment can regulate the epigenetic state and cell reprogramming. However, whether intracellular mechanical properties regulate cell reprogramming remains unknown. Here, we show for the first time, that the mechanical property of cells is modulated during the early phase of reprogramming as determined by atomic force microscopy (AFM) and high-throughput quantitative deformability cytometry (q-DC). We… More >
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