Ning Wang1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 21-21, 2019, DOI:10.32604/mcb.2019.07550
Abstract Decades ago YC Fung proposed that mechanical stress could have substantial impacts on remodeling and growth of living tissues. Fung also proposed the concept of residual stress in blood vessels and quantified residual stress in excised arteries [1]. However, how stress influences cell and tissue functions remains elusive. At the cellular level, we have quantified myosin II mediated pre-existing tensile stress (prestress) in living cells and demonstrated that the prestress (the endogenous cytoskeletal tension) regulates cell stiffness, gene expression, and long-distance stress propagation in the cytoplasm to activate enzymes [2]. The prestress even impacts on force-induced direct chromatin stretching and… More >
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