Zongkun Hou1, Shilei Hao1, Bochu Wang1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 145-145, 2019, DOI:10.32604/mcb.2019.07077
Abstract An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. The cortical folding has been implicated in neurodevelopmental disorders and yet its origins remain unknown. In vitro culture of 3D cerebral organoids from human pluripotent stem cells has been used to study the fundamental mechanisms of mammalian neurodevelopment and characteristics of human brain development. Here, we explores the mechanism of boundary limitation on the formation of gyri and sulci through the self-organization of human brain organoids. The structure of cerebral organoids was analyzed by morphology observation, pathology and immunofluorescence. The different… More >
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