Wensong LIU1, Yunjie LU1, Dong ZHANG1, Longqing SHI1, Guangchen ZU1, Haijiao YAN2,*, Donglin SUN1,*
BIOCELL, Vol.44, No.1, pp. 73-80, 2020, DOI:10.32604/biocell.2020.08613
Abstract Pancreatic cancer is one of the most aggressive malignancies with poor prognosis and high mortality.
Recent studies showed that microRNAs are dysregulated and involved in the initiation and progression of pancreatic
cancer. In this study, we found that miR-708 was significantly downregulated in pancreatic cancer tissues and cell
lines. Lentivirus-mediated overexpression of miR-708 could significantly inhibit the proliferation and invasion, while
enhanced chemosensitivity to gemcitabine in both Panc-1 and SW1990 cells. Luciferase reporter assay showed that
miR-708 bound the 3’-untranslated region of survivin and suppressed the expression of survivin in pancreatic cancer
cells. In pancreatic cancer tissues, survivin protein was… More >
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