MASOUMEH OGHABI1,2, AVA SAFAROGHLI-AZAR1,2, ATIEH POURBAGHERI-SIGAROODI1,2, MOHAMMAD SAYYADI3, MOHSEN HAMIDPOUR1, MOHAMMAD HOSSEIN MOHAMMADI1, DAVOOD BASHASH1,*
BIOCELL, Vol.44, No.2, pp. 183-192, 2020, DOI:10.32604/biocell.2020.08880
Abstract Pathogenesis of chronic myeloid leukemia (CML) has mostly been studied with regard to the oncogenic role
of BCR/ABL fusion; however, recent disclosures have declared that the challenges with the treatment of CML patients
would not be resolved until the role of other aberrancies is ignored. Given the involvement of cyclin-dependent kinases
(CDKs) in the pathogenesis of CML, the present study aimed to investigate the effects of a multi-CDK inhibitor
AT7519 on BCR/ABL-harboring CML-derived K562 cells. Our results showed that AT7519 effectively reduced the
survival of K562 and induced its anti-proliferative effect through the induction of G2/M arrest due to elevated… More >
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