BINFEN HOU1, LI ZHAO1, T IANHAO ZHAO1, MINGMING YANG1, WANWAN ZHU1, XIAODONG CHEN2, XIQUAN KE1, ZHENZENG MA1, LIN GU1, MENG WANG1, MIN DENG1,*
BIOCELL, Vol.47, No.1, pp. 175-186, 2023, DOI:10.32604/biocell.2022.021359
Abstract Aim: Gastric cancer (GC) is one of the most common malignant tumors. Chrysophanol has been reported to
possess antitumor effects on a variety of cancers; however, its role in GC remains unclear. This study aimed to investigate
the effects of chrysophanol on the proliferation, pyroptosis, migration, and invasion of GC cells. Methods: Human GC
cell lines MKN 28 and AGS cells were treated with different concentrations of chrysophanol, then cell proliferation,
migration, invasion and pyroptosis were determined by CCK-8, colony-forming assay, wound healing assay, Transwell
assay, and flow cytometry. Cell migration and invasion were reassessed in these transfected cells following… More >
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