CHAO NIU1,#, RUOFEI SUN1,#, XIAOGANG LI2, BO LI2, XIAODONG HE1,*
BIOCELL, Vol.47, No.10, pp. 2301-2312, 2023, DOI:10.32604/biocell.2023.029935
Abstract Objective: Breast cancer is a major cancer threatening the health of women globally. To elucidate the effect of the circHIAT1/miR-19a-3p/phosphatase and tensin homolog (PTEN) axis on regulating the malignant phenotype of breast cancer cells. Methods: The mRNA expression pattern of circHIAT1, miR-19a-3p, and PTEN was checked by real-time quantitative polymerase chain reaction. Then, the knockdown assay was carried out to explore the effect of circHIAT1 and miR-19a-3p on breast cancer. The relative cell experiments, including MTT assay, scratch assay, transwell invasion assay, and flow cytometry analysis, were conducted to verify the influence of circHIAT1 and miR-19a-3p on breast cancer cells.… More >
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