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    REVIEW

    Autophagy and circadian rhythms: interactions and clinical implications

    TIANKAI DI1,2,#, ZHIFEI ZHOU3,#, FEN LIU4,#, YUJIANG CHEN5,*, LULU WANG1,*

    BIOCELL, Vol.48, No.1, pp. 33-45, 2024, DOI:10.32604/biocell.2023.031638

    Abstract Autophagy is a widespread biological process that controls cellular growth, survival, development, and death. Circadian rhythm is a recurring reaction of living organisms and behaviors to variations in surrounding brightness and obscurity. Most of the fundamental physiological processes in mammals, such as the sleep-wake pattern and the rhythm of nutrition and energy metabolism, are governed by circadian rhythms. Research has indicated that autophagy exhibits a specific circadian pattern in both normal and abnormal conditions. Autophagy can modulate circadian rhythms by breaking down proteins that regulate the circadian clock. The potential regulatory connection between the two has been a popular subject… More >

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