Tiangen WU1, Tianhao BAO2,3, Daoming LIANG1,*, Lin WANG4,*
BIOCELL, Vol.43, No.4, pp. 293-298, 2019, DOI:10.32604/biocell.2019.07841
Abstract Circulating tumor cells (CTCs) are crucial to tumor metastasis, and they usually undergo epithelial–
mesenchymal transition (EMT) in order to disseminate from the primary tumor. However, very little is currently
known about the relationship between EMT and malignant phenotypes of CTCs in the context of gastric cancer.
Therefore, this study aimed to investigate the contribution of EMT to malignant phenotypes of CTCs derived from
gastric cancer cells. We xenografted MKN28 gastric cancer cells pretreated with transforming growth factor-beta 1
(TGFβ-1) into nude mice by intravenous injection. Next, we isolated CTCs from the blood of nude mice by gradient
centrifugation and… More >
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