Zhongyi Mu*†1, Dan Dong*1, Ning Wei‡§, Mingli Sun¶, Wei Wang*, Yue Shao*, Jian Gao*, Ping Yin*, Chenghai Zhao*
Oncology Research, Vol.27, No.6, pp. 653-661, 2019, DOI:10.3727/096504018X15420748671075
Abstract The lncRNA AFAP1-AS1, oriented from an antisense direction to the protein-coding gene AFAP1 in the opposite strand, was upregulated in a variety of tumors and associated with poor prognosis, including lung cancer,
breast cancer, ovarian cancer, and so on. However, the biological role of AFAP1-AS1 in clear cell renal cell
carcinoma (ccRCC) is still unknown. We observed that AFAP1-AS1 expression was significantly upregulated
in ccRCC tissues and that patients with high-level expression of AFAP1-AS1 had a shorter overall survival.
Knockdown of AFAP1-AS1 markedly suppressed the progression of proliferation, invasion, migration, and
EMT in ccRCC cells. Downregulation of AFAP1-AS1 resulted in… More >
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