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  • Open Access

    ARTICLE

    Tannin Nanoparticles (NP99) Enhances the Anticancer Effect of Tamoxifen on ER+ Breast Cancer Cells

    Faizah A. AlMalki1, Aziza M. Hassan2,*, Zeinab M. Klaab1, Soliman Abdulla3, Antonio Pizzi4

    Journal of Renewable Materials, Vol.9, No.12, pp. 2077-2092, 2021, DOI:10.32604/jrm.2021.016173

    Abstract Recently, natural substances in the form of nanoparticles are increasingly being used in different field, particularly in medicines to enhance their beneficial effects in treatment and prevention. Cancer cells of the breast (MCF-7) have been chosen to be examined and treated in vitro with conventional drug Tamoxifen (Tam) and tannin nanoparticles extract (NP99) individually or in combination. MTT reagent has been applied to assess the cell viability and propagation percentage, DNA fragmentation and mRNA relative expression of apoptotic genes to study the cell death pathway. The results showed that Tam and tannin NP99 triggered cytotoxic activity towards the MCF-7 cell.… More >

  • Open Access

    ARTICLE

    Isocyanate-Free Polyurethanes by Coreaction of Condensed Tannins with Aminated Tannins

    M. Thébault1,2, A. Pizzi13*, F.J. Santiago-Medina1, F.M. Al-Marzouki3, S. Abdalla3

    Journal of Renewable Materials, Vol.5, No.1, pp. 21-29, 2017, DOI:10.7569/JRM.2016.634116

    Abstract Isocyanate-free polyurethane resins biosourced to a very high percentage level were prepared by the reaction of aminated mimosa tannin extract with commercial mimosa tannin extract prereacted with dimethyl carbonate. The reaction took place with ease at ambient temperature. Indications were that the polyurethanes obtained formed a hard film when cured at a temperature higher than 100 °C. Furthermore, the carbohydrate fraction of the tannin extract also appeared to be carbonated and reacted to generate isocyanate-free polyurethane linkages with the aminated tannins. This indicated that not only the polyphenolic fraction of the tannin extract, but also its other major component, can… More >

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