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  • Open Access

    CASE REPORT

    Neocuspidization of the Pulmonary Valve with Autologous Pericardium in the Adult Patient with Ventricular Septal Defect and Infective Endocarditis: A Case Report and Review of the Literature

    Igor Mokryk1,2,*, Vitaly Demyanchuk1,2, Volodymyr Vashkeba2, Ilya Nechay1, Borys Todurov1,2

    Congenital Heart Disease, Vol.17, No.6, pp. 641-646, 2022, DOI:10.32604/chd.2022.025096

    Abstract Congenital heart disease (CHD) is one of the risk factors for developing infective endocarditis (IE). Right-sided IE occurs in 5%–10% of endocarditis cases, and pulmonary valve (PV) is involved in less than 2% of such patients. Literature data are few, and optimal treatment methods, indications for surgery, and types of operative techniques are still under debate. We present an adult patient with a rare combination of the ventricular septal defect (VSD) and PV IE who underwent surgical treatment. Neocuspidization with autologous pericardium was utilized for the reconstruction of his PV. We discuss details of this More > Graphic Abstract

    Neocuspidization of the Pulmonary Valve with Autologous Pericardium in the Adult Patient with Ventricular Septal Defect and Infective Endocarditis: A Case Report and Review of the Literature

  • Open Access

    REVIEW

    Associations between Bodyweight and Clinical Outcome in Patients Post-Fontan Procedure: A Systematic Review

    Emma Payne1,2, Thomas Wilson2,3, Marjan Haghighi1,4, Zoe McCallum2,3, Yves d’Udekem5, Julian Ayer1,4,*

    Congenital Heart Disease, Vol.17, No.6, pp. 617-639, 2022, DOI:10.32604/chd.2022.024775

    Abstract Background: Patients born with a single ventricle circulation commonly experience growth failure in early life, which is associated with adverse outcomes in infancy. However, associations between bodyweight or weight trajectory and clinical outcome post-Fontan procedure are yet to be determined. Methods: On the 1st of July 2021, a systematic review was performed in MEDLINE, EMBASE, the Cochrane Library, and Scopus of studies of patients with clinical outcome data post-Fontan procedure and association with bodyweight. Quality of studies was evaluated by Newcastle–Ottawa scale for cohort studies and Joanna Briggs Institute tool for cross-sectional studies. Results: Of 527 studies… More >

  • Open Access

    ARTICLE

    NOTCH3 Mutations and CADASIL Phenotype in Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

    Rui Jiang1,3,*, Kaisheng Lai2, Jianping Xu1, Xiang Feng1, Shaoye Wang1, Xiaojian Wang3, Zhe Liu2

    Congenital Heart Disease, Vol.17, No.6, pp. 675-686, 2022, DOI:10.32604/chd.2022.021626

    Abstract Background: The etiology of pulmonary arterial hypertension associated with congenital heart disease (PAHCHD) is complicated and the phenotype is heterogeneous. Genetic defects of NOTCH3 were associated with cerebral disease and pulmonary hypertension. However, the relationship between NOTCH3 mutations and the clinical phenotype has not been reported in CHD-PAH. Methods: We eventually enrolled 142 PAH-CHD patients from Fuwai Hospital. Whole exome sequencing (WES) was performed to screen the rare deleterious variants of NOTCH3 gene. Results: This PAH-CHD cohort included 43 (30.3%) men and 99 (69.7%) women with the mean age 29.8 ± 10.9 years old. The pathogenic or likely pathogenic… More >

  • Open Access

    ARTICLE

    Factors Affecting the Genetic Diagnostic Rate in Congenital Heart Disease

    Jun Sung Park1, Go Hun Seo2, Yunha Choi1, Soojin Hwang1, Minji Kang3, Hyo-Sang Do3, Young-Hwue Kim4, Jeong Jin Yu4, Ellen Ai-Rhan Kim5, Euiseok Jung5, Byong Sop Lee5, Jae Suk Baek4, Beom Hee Lee1,6,*

    Congenital Heart Disease, Vol.17, No.6, pp. 653-673, 2022, DOI:10.32604/chd.2022.021580

    Abstract Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally, multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This study investigated the diagnostic yield of whole-exome sequencing (WES) in patients with sporadic syndromic CHD and the phenotypic factors affecting the genetic diagnostic rate. Methods: Sixty-four patients with sporadic syndromic CHD aged <18 years underwent WES between May 2018 and December 2020 in a single tertiary center, and the association between genetic testing data and extracardiac phenotypes was analyzed. Results: Extracardiac phenotypes were measured as 3.66 ± 3.05 (standard deviation,… More > Graphic Abstract

    Factors Affecting the Genetic Diagnostic Rate in Congenital Heart Disease

  • Open Access

    ARTICLE

    Prevalence of Congenital Heart Disease at Extremely High Altitudes in Tibet and the Establishment of a New Free Treatment Model

    Shuting Chang1,2, Guanzhao Zhang2,3, Nengjun Sun2, Xinpeng Yuan4, Qingting Wang5, Lin Zhu6, Feiyue Zhang7, Yu Xiu4, Yang Dong8, Yonghong Chen9, Zhanpeng Zhao10, Xiao Liu4, Qiang Shao11, Xiaofeng Xu12, Anshun Wang13, Mengjiao Li14, Bo Li2,*

    Congenital Heart Disease, Vol.17, No.6, pp. 709-716, 2022, DOI:10.32604/chd.2022.018657

    Abstract Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitude areas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and treatment for the Tibetan population. Methods: A total of 2242 students from different schools in Ngamring County, Xigaze city, Tibet from September 2019 to September 2020 were selected for screening. The students were examined through the inquiry of their current medical history and family history, cardiac auscultation and a physical examination, in order to screen out the suspected cases of… More >

  • Open Access

    ARTICLE

    Emotions, Perceptions and Health Behaviors of Adult Congenital Heart Disease Patients during COVID-19 in New York City

    Jodi L. Feinberg1, Peter Sheng2, Stephanie Pena2, Adam J. Small1, Susanna Wendelboe1, Katlyn Nemani3, Vikram Agrawal4, Dan G. Halpern1,*

    Congenital Heart Disease, Vol.17, No.5, pp. 519-531, 2022, DOI:10.32604/chd.2022.024174

    Abstract Background: Adults with congenital heart disease (ACHD) have increased prevalence of mood and anxiety disorders. There are limited data regarding the influence of the COVID-19 pandemic on the mental health and health behaviors of these patients. Objective: The purpose is to evaluate the perceptions, emotions, and health behaviors of ACHD patients during the COVID-19 pandemic. Methods: In this cross-sectional study of ACHD patients, we administered surveys evaluating self-reported emotions, perceptions and health behaviors. Logistic regressions were performed to determine the adjusted odds of displaying each perception, emotion and health behavior based on predictor variables. Results: Ninety-seven patients… More > Graphic Abstract

    Emotions, Perceptions and Health Behaviors of Adult Congenital Heart Disease Patients during COVID-19 in New York City

  • Open Access

    ARTICLE

    Incidence and Related Risk Factors of Junctional Ectopic Tachycardia in Infants after Cardiac Surgery for Congenital Heart Disease

    Jae Hee Seol1,4,#, Se Yong Jung1,#, Jae Young Choi1, Han Ki Park2, Young Hwan Park2, Nam Kyun Kim1,3,*

    Congenital Heart Disease, Vol.17, No.5, pp. 569-578, 2022, DOI:10.32604/chd.2022.018436

    Abstract Objective: Junctional ectopic tachycardia is common after cardiac surgery for congenital heart disease. However, its incidence and related risk factors in infants after cardiac surgery are not well known. The objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and infants. Methods: We enrolled a total of 271 patients aged <1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December 2020. Exclusion criteria were immediate postoperative mortality, other arrhythmias detected in the perioperative period, and prematurity. Result: The overall incidence of… More >

  • Open Access

    ARTICLE

    Mortality and Long-Term Outcome of Neonates with Congenital Heart Disease and Acute Perinatal Stroke: A Population-Based Case-Control Study

    Eszter Vojcek1,2,*, V. Anna Gyarmathy3,4, Rozsa Graf5, Anna M. Laszlo6, Laszlo Ablonczy7, Zsolt Prodan7, Istvan Seri1,8

    Congenital Heart Disease, Vol.17, No.4, pp. 447-461, 2022, DOI:10.32604/chd.2022.022274

    Abstract Objective: Neonates with congenital heart disease (CHD) and perinatal stroke have high mortality and survivors are at risk for poor long-term neurodevelopmental outcome. The aim of this study was to assess the risk factors and outcome of neonates with both CHD and MRI-confirmed perinatal stroke (Study Group) and compare those to the risk factors and outcome of infants matched for CHD without stroke (Control-1) and of infants matched for MRI-confirmed stroke without CHD (Control-2). Methods: We conducted a population-based case-control study enrolling 28 term neonates with CHD and MRI-confirmed acute perinatal stroke born between 2007–2017 in… More > Graphic Abstract

    Mortality and Long-Term Outcome of Neonates with Congenital Heart Disease and Acute Perinatal Stroke: A Population-Based Case-Control Study

  • Open Access

    ARTICLE

    Comparison of Intracardiac and Extracardiac Malformations Associated with Single Atrium, Single Ventricle and Single Atrium-Single Ventricle Using DualSource Computed Tomography

    Tong Pang#, Li Jiang#, Yi Zhang, Mengxi Yang, Jin Wang, Yuan Li*, Zhigang Yang*

    Congenital Heart Disease, Vol.17, No.4, pp. 479-489, 2022, DOI:10.32604/chd.2022.020401

    Abstract Background: To evaluate the qualitative and quantitative differences between intracardiac and extracardiac vascular malformations in patients with a single atrium (SA), single ventricle (SV) and single atrium-single ventricle (SA-SV) using dual-source CT (DSCT), and to compare the diagnostic performances of DSCT and transthoracic echocardiography (TTE). Methods: This retrospective study included 24 SA, 75 SV and 24 SA-SV patients who underwent both DSCT and TTE before surgery. The diagnostic values of DSCT and TTE for intracardiac and extracardiac malformations were compared according to the surgical results. The diameters of the major artery and vein were measured and calculated… More >

  • Open Access

    ARTICLE

    Adults with Congenital Heart Disease during the COVID-19 Era: One-Year Tertiary Center Experience

    Fatma A. Taha1,2,*, Osama Amoudi1, Fareed Alnozha1, Reda Abuelatta1

    Congenital Heart Disease, Vol.17, No.4, pp. 399-419, 2022, DOI:10.32604/chd.2022.020174

    Abstract Background: Adult patients with congenital heart disease (ACHD) might be at high risk of Coronavirus disease- 2019 (COVID-19). This study aimed to report on a one-year tertiary center experience regards COVID-19 infection in ACHD patients. Methods: This is a one-year (March-2020 to March-2021) tertiary-center retrospective study that enrolled all ACHD patients; COVID-19 positive patients’ medical records, and management were reported. Results: We recorded 542 patients, 205 (37.8%) COVID-19-positive, and 337 (62.2%) COVID-19-negative patients. Palliated single ventricle and Eisenmenger syndrome patients were more vulnerable to COVID-19 infection (P < 0.05*). Cardiovascular COVID-19 complications were arrhythmias in 47 (22.9%)… More >

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