Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (272)
  • Open Access

    ARTICLE

    Predicting Factors of Physical Activity among Children with Congenital Heart Disease after Corrective Surgery

    Nuttanicha Sriboonyawattana*, Thitima Suklerttrakul

    Congenital Heart Disease, Vol.20, No.2, pp. 231-244, 2025, DOI:10.32604/chd.2025.064662 - 30 April 2025

    Abstract Objective: Many children with fully corrected congenital heart disease (CHD) avoid physical activity (PA). This descriptive study sought to determine child and parental factors that could predict PA levels in Thai children after corrective surgery. Methods: Ninety school-aged children with fully corrected CHD were recruited from a cardiology clinic at a university hospital in northern Thailand. Data collection involved five validated questionnaires: (1) the Modified Thai Adolescent’s Physical Activity Questionnaire, (2) the Child Health Status Questionnaire-Forms I and II, (3) the Parental Knowledge on School-aged Children’s Physical Activity Scale, (4) the Perceived Self-efficacy to Physical Activity… More >

  • Open Access

    REVIEW

    Variants and Molecular Mechanism of NOTCH1 in Congenital Heart Disease

    Hongqun Xiang1, Jian Zhuang2,3, Luoning Bao4,5, Yan Shi2,3,*

    Congenital Heart Disease, Vol.20, No.2, pp. 245-263, 2025, DOI:10.32604/chd.2025.064366 - 30 April 2025

    Abstract Congenital heart disease (CHD) is the most common birth defect, with 34% of cases attributed to genetic variants. NOTCH1, a multi-domain transmembrane protein, regulates heart development by controlling the differentiation and migration of myocardial mesoderm cells, and different variants are present in different types of CHD. In this review, we aim to provide a detailed description of NOTCH1 structural domains and their functions, highlighting NOTCH1 variants in CHD and the molecular mechanisms through which they contribute to CHD occurrence. NOTCH1 has two main domains, the NOTCH extracellular domain (NECD) and the NOTCH intracellular domain… More >

  • Open Access

    ARTICLE

    Hemodynamic Profile Based on Right Heart Catheterization in Adult Acyanotic Congenital Heart Disease with Pulmonary Hypertension

    Dina Anggraini1, Kurnia Wahyudi2, Melawati Hasan3, Sri Endah Rahayuningsih4,*, Charlotte Johanna Cool3

    Congenital Heart Disease, Vol.20, No.2, pp. 133-141, 2025, DOI:10.32604/chd.2025.064164 - 30 April 2025

    Abstract Background: Congenital heart disease (CHD) occurs in 9 out of 100 births and is the leading cause of birth defects, with acyanotic CHD being more common. The incidence of adult CHD is rising faster than pediatric CHD. Pulmonary hypertension is the most common complication in untreated CHD patients. Methods: This study is retrospective descriptive research based on medical record data and the results of right heart catheterization examinations in adult acyanotic CHD aged ≥18 years and free from other organ disorders. Results: A total of 103 patients met the inclusion criteria, the majority were young… More >

  • Open Access

    ARTICLE

    Generating Synthetic Data for Machine Learning Models from the Pediatric Heart Network Fontan I Dataset

    Vatche Bahudian, John Valdovinos*

    Congenital Heart Disease, Vol.20, No.1, pp. 115-127, 2025, DOI:10.32604/chd.2025.063991 - 18 March 2025

    Abstract Background: The population of Fontan patients, patients born with a single functioning ventricle, is growing. There is a growing need to develop algorithms for this population that can predict health outcomes. Artificial intelligence models predicting short-term and long-term health outcomes for patients with the Fontan circulation are needed. Generative adversarial networks (GANs) provide a solution for generating realistic and useful synthetic data that can be used to train such models. Methods: Despite their promise, GANs have not been widely adopted in the congenital heart disease research community due, in some part, to a lack of knowledge… More >

  • Open Access

    REVIEW

    Maternal Diabetes Mellitus and Congenital Heart Diseases: Systematic Review

    Roberto Noya Galluzzo1, Karine Souza Da Correggio1, Aldo von Wangenheim2, Heron Werner3, Nathalie Jeanne Bravo-Valenzuela4, Edward Araujo Júnior5,6,*, Alexandre Sherlley Casimiro Onofre7

    Congenital Heart Disease, Vol.20, No.1, pp. 89-101, 2025, DOI:10.32604/chd.2025.063014 - 18 March 2025

    Abstract Introduction: Diabetes mellitus (DM), a metabolic disorder, leads to organ damage due to chronic hyperglycemia with multiple pathogenic processes. Gestational diabetes mellitus (GDM) poses risks to mothers and offspring, increasing the incidence of structural congenital heart disease (CHD) and myocardial hypertrophy in newborns. Objective: This review aimed to examine the association between maternal diabetes mellitus and CHD. Methods: This systematic review used the STROBE and TRIPOD checklists registered in PROSPERO (CRD42024513858). It focused on diagnostic test accuracy using the Munn et al. protocol for systematic assessment, emphasizing the “PIRD”: Population, Index Test, Reference Test, Diagnosis of Interest.… More >

  • Open Access

    REVIEW

    Challenges in the Transition and Transfer of Young Adults with Congenital Heart Disease in Latin America and the Caribbean: The “Timeliness Principle”

    John J. Araujo1,2,*

    Congenital Heart Disease, Vol.20, No.1, pp. 61-75, 2025, DOI:10.32604/chd.2025.062927 - 18 March 2025

    Abstract Today, more than 90% of children who are born with congenital heart disease survive and reach adulthood, especially in developed countries. Consequently, the population of adults with congenital heart disease has increased significantly over the last few decades. In Latin America and the Caribbean countries, this same scenario is occurring at an accelerated pace. Loss to follow-up is a global problem in adults with congenital heart disease, ranging from 30–60%. In Latin America and Caribbean countries, it is estimated that less than 10% of adults with congenital heart disease are being followed. The small number More >

  • Open Access

    REVIEW

    Climate Change and Congenital Heart Disease: A Narrative Review

    Ethan Katznelson1, Matthew J. Navarro2, Su Yuan1, Dhurv S. Kazi3, Harsimran S. Singh1,*

    Congenital Heart Disease, Vol.19, No.6, pp. 627-634, 2024, DOI:10.32604/chd.2025.062309 - 27 January 2025

    Abstract Congenital Heart Disease (CHD) is the most common birth defect and a leading cause of infant morbidity and mortality worldwide. While genetic factors play a significant role in its development, up to 30% of CHD is associated with modifiable risk factors and external maternal exposures. Climate change, driven by increased atmospheric pollutants from fossil fuel combustion, leads to rising global temperatures and worsening air quality, which pose emerging threats to maternal and fetal health. This review explores the mechanisms by which environmental factors associated with climate change, specifically extreme heat and air pollution, may influence… More >

  • Open Access

    REVIEW

    Surgical Ablation in Congenital Heart Disease: Advances in Techniques and Clinical Outcomes

    Manouk H. C. Linderhof1,#, Hoang H. Nguyen1,2,#, Annemien E. van den Bosch1, Mathijs S. van Schie1, Vehpi Yildirim1, Yannick J. H. J. Taverne3, Natasja M. S. de Groot1,*

    Congenital Heart Disease, Vol.19, No.6, pp. 577-592, 2024, DOI:10.32604/chd.2025.062129 - 27 January 2025

    Abstract Surgical ablation (SA) has become an essential rhythm-control strategy for managing tachyarrhythmias in patients with congenital heart disease. Atrial tachyarrhythmias, such as atrial flutter and atrial fibrillation, are prevalent in congenital heart disease, affecting up to 50% of patients, and pose significant risks, including increased morbidity and mortality. Ventricular tachyarrhythmias, though less common, can lead to sudden cardiac death, particularly in conditions like Tetralogy of Fallot. Prior studies suggested that SA for tachyarrhythmias in patients with congenital heart disease offers significant benefits, including superior long-term rhythm control compared to catheter ablation (CA). Atrial tachyarrhythmia burden… More > Graphic Abstract

    Surgical Ablation in Congenital Heart Disease: Advances in Techniques and Clinical Outcomes

  • Open Access

    ARTICLE

    The Factors for Postoperative Peritoneal Dialysis Treatment in Infants after Congenital Cardiac Procedure

    Xiaofeng Wang#, Chenyu Li#, Xia Li, Zhongyuan Lu, Xu Wang*

    Congenital Heart Disease, Vol.19, No.6, pp. 617-626, 2024, DOI:10.32604/chd.2025.058712 - 27 January 2025

    Abstract Objectives: Fluid overload is common after congenital cardiac surgeries. This requires early application of peritoneal dialysis (PD) in infants to improve surgical outcomes. The objective of this study is to ascertain the factors correlated with the necessity for PD in infants, thereby informing the prophylactic placement of PD catheters intraoperatively. Methods: This was a single-center retrospective study. Infants aged three months or younger who underwent congenital cardiac procedures at the Fuwai Hospital between 2021 and 2022 were included. Patients with chronic renal failure or without RACHS-1 categories were excluded. Based on whether postoperative PD treatment… More >

  • Open Access

    CASE REPORT

    Case Report: Prominent Coronary Artery Flow in Fetuses with Congenital Heart Disease, Is It a Marker of In Utero Distress?

    Mohamed Aashiq Abdul Ghayum1,*, Maria Kiaffas1,2, Ashley Warta1, Melanie Kathol1, David C. Mundy2, Kelsey Brattrud1, Nitin Madan1,2

    Congenital Heart Disease, Vol.19, No.6, pp. 647-651, 2024, DOI:10.32604/chd.2025.058271 - 27 January 2025

    Abstract Prominent coronary artery (CA) flow observed on a fetal echocardiogram has been associated with fetal growth restriction and myocardial dysfunction. We present two cases with this finding, in the presence of congenital heart disease (CHD) and absence of growth restriction or myocardial dysfunction. Both the cases rapidly progressed to extremis, necessitating emergent delivery. Our cases highlight the importance of recognizing prominent CA flow in fetuses with CHD as a potential marker for in utero distress. More >

Displaying 1-10 on page 1 of 272. Per Page