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  • Open Access

    ARTICLE

    Having a Partner and Having Children: Comparisons of Adults with Congenital Heart Disease and the General Population: A 15-Year Case-Control Study

    Siegfried Geyer1,*, Claudia Dellas2, Thomas Paul2, Matthias Müller2, Kambiz Norozi2,3,4

    Congenital Heart Disease, Vol.18, No.3, pp. 337-348, 2023, DOI:10.32604/chd.2023.028827

    Abstract Objectives: To examine whether patients with congenital heart disease (CHD) are less likely to have a partner or children than individuals from the general population. Methods: Longitudinal study with two assessments of the same patients (n = 244) from a hospital population and controls (n = 238) from the German Socio-Economic Panel (GSOEP) using parental education, patients age, and sex as matching criteria. The first patient study was conducted between 5/2003 and 6/2004, the second one between 5/2017 and 4/2019. Controls were drawn from GSOEP-surveys 2004 and 2018. CHD-severity was classified according to type of… More > Graphic Abstract

    Having a Partner and Having Children: Comparisons of Adults with Congenital Heart Disease and the General Population: A 15-Year Case-Control Study

  • Open Access

    ARTICLE

    Role of Surgery on Growth of Tricuspid Valve in Pulmonary Atresia with Intact Ventricular Septum: Mid-Term Results of Modified Right-Ventricular Overhauling Procedure

    Jae Gun Kwak1, Eung Re Kim2, Taeyoung Yun1, Sungkyu Cho1, Chang-Ha Lee2, Woong-Han Kim1,*

    Congenital Heart Disease, Vol.18, No.3, pp. 325-336, 2023, DOI:10.32604/chd.2023.027758

    Abstract Objectives: To access the effectiveness of our modified right-ventricular overhauling procedure on tricuspid valve (TV) growth in patients with pulmonary atresia with intact ventricular septum (PAIVS). Methods: We retrospectively reviewed 21 patients with PAIVS who underwent modified right ventricular overhauling (mRVoh) between 2008 and 2019 at two institutions. Our mRVoh consisted of wide resection of hypertrophied infundibular and trabecular muscle, peeling off fibrotic endocardial tissue in the right ventricle (RV) cavity, surgical pulmonary valvotomy, and Blalock-Taussig shunt or banding of ductus arteriosus under cardiopulmonary bypass. The TV annulus sizes were measured and analyzed using echocardiography… More > Graphic Abstract

    Role of Surgery on Growth of Tricuspid Valve in Pulmonary Atresia with Intact Ventricular Septum: Mid-Term Results of Modified Right-Ventricular Overhauling Procedure

  • Open Access

    ARTICLE

    Delivery Outcomes in Non-Tertiary Referral Centers for Women with Congenital Heart Disease

    Daniel Sweeney1, Scott Cohen2,3, Salil Ginde2,3, Jennifer Gerardin2,3, Peter Bartz2,3, Matthew Buelow2,3,*

    Congenital Heart Disease, Vol.18, No.3, pp. 315-323, 2023, DOI:10.32604/chd.2023.027349

    Abstract Background: Women with congenital heart disease (CHD) have increased risk for adverse events during pregnancy and delivery. Prior studies have assessed pregnancy and delivery outcomes at tertiary referral centers (TRC). The aim of our study was to assess pregnancy outcomes in women with CHD who deliver in a non-tertiary referral center (non-TRC). Methods: Clinical demographics were collected, including anatomic complexity, physiologic state and pre-pregnancy risk assessment. Patients were stratified by delivery location, either TRC or non-TRC. Maternal and neonatal complications of pregnancy were reported. Results: Women with CHD who delivered in a TRC had a higher… More > Graphic Abstract

    Delivery Outcomes in Non-Tertiary Referral Centers for Women with Congenital Heart Disease

  • Open Access

    ARTICLE

    Outcomes of Self-Expanding Transcatheter Pulmonary Valves: Extended Follow-Up of a Prospective Trial

    Jingnan Zhang1, Junyi Wan1, Yihang Li2, Yu Han2, Jiahua Pan3, Fang Fang1, Shiliang Jiang4, Xiangbin Pan1, Gejun Zhang1,*

    Congenital Heart Disease, Vol.18, No.2, pp. 219-234, 2023, DOI:10.32604/chd.2023.027562

    Abstract Background: The Venus-P valve was the first self-expanding valve used world-wide for transcatheter pulmonary valve replacement (TPVR) in patients with severe pulmonary regurgitation (PR). We intended to report the extended follow-up results from the prospective trial (No. NCT02590679). Methods: A total of 38 patients with severe PR (mean age 24.2 ± 13.2) were included. Follow-up data were obtained after implanted at 1, 6, and 12 months and yearly after. The frame geometry was assessed on post-implant computer tomography (CT) scanning by calculating the non-circularity [circularity ratio (minimum diameter/maximum diameter) < 0.9] and under-expansion [expansion ratio (derived external valve… More > Graphic Abstract

    Outcomes of Self-Expanding Transcatheter Pulmonary Valves: Extended Follow-Up of a Prospective Trial

  • Open Access

    REVIEW

    The Prevalence of Congenital Heart Disease among School-Age Children in China: A Meta-Analysis and Systematic Review

    Shuqin Zhang1,#, Bin Zhang2,#, Jianying Wu3, Jin Luo1, Haomin Shi1, Jirong Qi3,4,*, Huilian Yang1,5,*

    Congenital Heart Disease, Vol.18, No.2, pp. 127-150, 2023, DOI:10.32604/chd.2023.025616

    Abstract Objectives: To estimate the prevalence of Congenital Heart Disease (CHD) in school-age children, to identify the extent to which altitude affects the prevalence of the disease, and to examine trends in prevalence over time in China. Methods: Seven databases were systematically searched and last retrieved on September 10, 2021 for all studies reporting the prevalence of CHD in children after 1970 in China, which were then divided into high and low altitude regions based on 2500 meters above sea level. The random-effected model was used to combine prevalence data and subgroups analysis. The baseline data of… More > Graphic Abstract

    The Prevalence of Congenital Heart Disease among School-Age Children in China: A Meta-Analysis and Systematic Review

  • Open Access

    ARTICLE

    Cardiac Surgery with Cardiopulmonary Bypass in Low-Weight or Preterm Neonates: A Retrospective Study Analyzing Early Outcome

    Alain J. Poncelet1,*, Maureen Peers de Nieuwburgh2, Stéphane Moniotte2, Geoffroy de Beco1, Karlien Carbonez2, Jean E. Rubay1, Thierry Detaille3, Laurent Houtekie3, Mona Momeni4

    Congenital Heart Disease, Vol.18, No.2, pp. 151-168, 2023, DOI:10.32604/chd.2023.022636

    Abstract Background: Most outcome studies in congenital cardiac surgery for “low weight” neonates include patients undergoing surgery without cardiopulmonary bypass (CPB). The primary objective of our study was to identify risk factors for in-hospital mortality in neonates weighing less than 3 Kg and undergoing surgery with CPB. In addition, we compared the effect of early surgery with CPB (before 37W-gestational age (GA)) for congenital heart disease to delayed surgery until a corrected GA of 37 weeks in an attempt to promote weight gain. Methods: Retrospective single-center study including all patients operated between 1997 and 2017. Uni- and… More >

  • Open Access

    ARTICLE

    Quality of Life in Congenital Heart Disease Patients According to Their Anatomical and Physiological Classification

    Efrén Martínez-Quintana1,2,*, Hiurma Estupiñán-León2, Ana Beatriz Rojas-Brito2, Liuva Déniz-Déniz2, Alejandro Barreto-Martín2, Fayna Rodríguez-González3

    Congenital Heart Disease, Vol.18, No.2, pp. 197-206, 2023, DOI:10.32604/CHD.2021.013308

    Abstract Background: Living well is as important as living longer. The objective of this study is to assess quality of life (QoL) in congenital heart disease (CHD) according to current AHA/ACC anatomical and physiological classifi- cation. Methods: Cross-sectional study examining the World Health Organization QoL Bref questionnaire (WHOQoL-Bref) in consecutive outpatient CHD patients from a single unit. Results: 191 CHD patients were studied. Median age was 28 ± 13 years and 59% were male. 44 (23%), 115 (60%) and 33 (17%) CHD patients showed mild, moderate and great anatomical defects respectively while 69 (36%) patients were in physiological… More >

  • Open Access

    ARTICLE

    Classifying Cardiac Anomalies in Right and Left Isomerism: Concordant and Discordant Patterns

    Lilia Oreto1,*, Giuseppe Mandraffino2, Paolo Ciliberti3, Teresa P. Santangelo4, Placido Romeo5, Antonio Celona5, Placido Gitto1, Lorenzo Galletti3, Fiore S. Iorio3, Alfredo Di Pino1, Aurelio Secinaro4, Paolo Guccione3, Robert H. Anderson6, Salvatore Agati1

    Congenital Heart Disease, Vol.18, No.1, pp. 97-111, 2023, DOI:10.32604/chd.2022.023619

    Abstract Aims: Evidence is emerging that, in the setting of isomerism, the atrial and bronchial arrangement are not always concordant, nor are these patterns always harmonious with the arrangement of the abdominal organs. We aimed to evaluate the concordance between these features in a cohort of patients with cardiac malformations in the setting of known isomerism, seeking to determine whether it was feasible to assess complexity on this basis, in this regard taking note of the potential value of bronchial as opposed to appendage morphology. Methods and Results: We studied 78 patients known to have isomerism of the… More > Graphic Abstract

    Classifying Cardiac Anomalies in Right and Left Isomerism: Concordant and Discordant Patterns

  • Open Access

    ARTICLE

    Assessment of Intracardiac and Extracardiac Deformities in Patients with Various Types of Pulmonary Atresia by Dual-Source Computed Tomography

    Wenlei Qian1,#, Xinzhu Zhou2,#, Ke Shi1, Li Jiang1, Xi Liu3, Liting Shen1, Zhigang Yang1,*

    Congenital Heart Disease, Vol.18, No.1, pp. 113-125, 2023, DOI:10.32604/chd.2023.023542

    Abstract Background: Pulmonary atresia (PA) is a group of heterogeneous complex congenital heart disease. Only one study modality might not get a correct diagnosis. This study aims to investigate the diagnostic power of dual-source computed tomography (DSCT) for all intracardiac and extracardiac deformities in patients with PA compared with transthoracic echocardiography (TTE). Materials and Methods: This retrospective study enrolled 79 patients and divided them into three groups according to their main diagnosis. All associated malformations and clinical information, including treatments, were recorded and compared among the three groups. The diagnostic power of DSCT and TTE on all associated… More > Graphic Abstract

    Assessment of Intracardiac and Extracardiac Deformities in Patients with Various Types of Pulmonary Atresia by Dual-Source Computed Tomography

  • Open Access

    ARTICLE

    Genetic Analysis of Variants of the MYH6 Gene Promoter in Congenital Atrial Septal Defects

    Ji-Yang Zuo1,2, Huan-Xin Chen1,2, Zhi-Gang Liu1,2, Qin Yang1,2, Guo-Wei He1,2,*

    Congenital Heart Disease, Vol.18, No.1, pp. 7-21, 2023, DOI:10.32604/chd.2022.025451

    Abstract Background: Atrial septal defect (ASD) is one of the common congenital heart diseases. The MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been explored. Methods: In 613 subjects including 320 ASD patients, we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics analysis. Results: Eleven variants were identified in the MYH6 gene promoter, of which four variants were found only in ASD patients, and two variants (g.3434G>C and g.4524C>T) were identified for the first… More > Graphic Abstract

    Genetic Analysis of Variants of the <i>MYH6</i> Gene Promoter in Congenital Atrial Septal Defects

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