Hongjian Wang*, Jie Zheng†, LiangWang‡, Akiko Maehara§, Chun YangII, David Muccigrosso†, Richard BachkII, Jian Zhu**, Gary S. Mintz§, Dalin Tang*,‡,††
Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 107-122, 2015, DOI:10.3970/mcb.2015.012.107
Abstract Computational modeling has been used extensively in cardiovascular and biological research, providing valuable information. However, 3D vulnerable plaque model construction with complex geometrical features and multicomponents is often very time consuming and not practical for clinical implementation. This paper investigated if 2D atherosclerotic plaque models could be used to replace 3D models to perform correlation analysis and achieve similar results. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from a patient follow-up study to construct 2D structure-only and 3D FSI models to obtain plaque wall stress (PWS) and strain (PWSn) data. One hundred and twenty-seven (127) matched IVUS… More >
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