Junfeng Lu*, Zhongsong Zhao†, Yanhong Ma‡
Oncology Research, Vol.28, No.5, pp. 509-518, 2020, DOI:10.3727/096504020X15954139263808
Abstract The present study aimed to investigate the effect of miR-186 on proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) of hepatocellular carcinoma (HCC). In this work, miR-186 was downregulated in HCC tissues and cells, and low miR-186 level helped predict the occurrence of vascular invasion and
poor prognosis in patients with HCC. miR-186 overexpression inhibited cell proliferation and tumor growth
in nude mice, repressed migration and invasion abilities, and enhanced apoptosis in HCC cells. miR-186 also
retarded progression of EMT. miR-186 directly bound to the 3 -untranslated regions of cyclin-dependent kinase
6 (CDK6) to inhibit its expression. Overexpression of CDK6 markedly… More >
Login
Register
